Profile-profile comparisons by COMPASS predict intricate homologies between protein families

Profile-profile comparisons by COMPASS predict intricate homologies between protein families.

Recently we proposed a novel method of alignment-alignment comparison, COMPASS (the tool for COmparison of Multiple Protein Alignments with Assessment of Statistical Significance). Here we present several examples of the relations between PFAM protein families that were detected by COMPASS and that lead to the predictions of presently unresolved protein structures. We discuss relatively straigh...

COACH: profile-profile alignment of protein families using hidden Markov models

MOTIVATION Alignments of two multiple-sequence alignments, or statistical models of such alignments (profiles), have important applications in computational biology. The increased amount of information in a profile versus a single sequence can lead to more accurate alignments and more sensitive homolog detection in database searches. Several profile-profile alignment methods have been proposed ...

A COMPARISON BETWEEN THE PROTEIN PROFILE OF lNT ACT AND TWO

The relationship between the full biophysical profile and rapid biophysical profile in antepartum fetal surveillance

Objective: one of the best tests for the assessment of a fetus is the biophysical profile test which has a significant effect on fetus health and the outcome of pregnancy. The present study was designed to determine the relationship between the full biophysical profile and the rapid biophysical profile tests in antepartum fetal surveillance. Patients and Methods: In this prospective study, Sin...

Weak Homology Detection by Profile-Profile Comparison

Experimentally determined protein tertiary structures are currently increasing in an enormous rate. The growth of the structure database makes structure prediction methods based on known tertiary structures more efficient. Detecting weak homology is crucial to extend applicable area of these methods. For this purpose, a profile or PSSM (position-specific score matrix) derived from multiple alig...